Pub. Date : 2013 Jan
PMID : 23051665
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aquaporin-4 deficiency attenuates opioid dependence through suppressing glutamate transporter-1 down-regulation and maintaining glutamate homeostasis. | Glutamic Acid | aquaporin 4 | Mus musculus |
| 2 | RESULTS: We found that AQP4 knockout prevented the down-regulations of GLT-1 expression and glutamate clearance when mice were repeatedly treated with morphine. | Glutamic Acid | aquaporin 4 | Mus musculus |
| 3 | In addition, AQP4 knockout abolished both decreases and increases in the extracellular glutamate levels in the prefrontal cortex during repeated morphine treatment and naloxone-precipitated withdrawal. | Glutamic Acid | aquaporin 4 | Mus musculus |
| 4 | CONCLUSION: AQP4 deficiency suppresses the down-regulation of GLT-1, and the disruption of glutamate homeostasis caused by repeated exposure to morphine, pointing to a strategy for maintaining glutamate homeostasis and thereby treating addiction through the modulation of AQP4 function and expression. | Glutamic Acid | aquaporin 4 | Mus musculus |
| 5 | CONCLUSION: AQP4 deficiency suppresses the down-regulation of GLT-1, and the disruption of glutamate homeostasis caused by repeated exposure to morphine, pointing to a strategy for maintaining glutamate homeostasis and thereby treating addiction through the modulation of AQP4 function and expression. | Glutamic Acid | aquaporin 4 | Mus musculus |