Title : Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.

Pub. Date : 2013 Jan

PMID : 23043184






3 Functional Relationships(s)
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1 The results show that CYP2E1 inhibits CYP2B4-mediated metabolism of benzphetamine (BNZ) with a K(i) of 0.04 microM. Benzphetamine cytochrome P450 family 2 subfamily E member 1 Homo sapiens
2 The results show that CYP2E1 inhibits CYP2B4-mediated metabolism of benzphetamine (BNZ) with a K(i) of 0.04 microM. Benzphetamine cytochrome P450 family 2 subfamily E member 1 Homo sapiens
3 Additionally, CYP2E1 increased the apparent K(M) of CYP2B4 for BNZ by 8-fold and the apparent K(M) did not decrease to its original value when saturating concentrations of CPR were used. Benzphetamine cytochrome P450 family 2 subfamily E member 1 Homo sapiens