Pub. Date : 2012 Oct 5
PMID : 23039130
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of Akt/NF-kappaB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Our study aimed to evaluate the antitumour effects of parthenolide, a NF-kappaB inhibitor, in two human glioblastoma cell lines (U87MG and U373) and in glioblastoma xenografts. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Furthermore, parthenolide reduced Akt phosphorylation and activated mitochondrial signalling, suggesting that the antitumour function of parthenolide may be mediated not only by the inhibition of NF-kappaB but also by the inhibition of Akt signalling and the activation of apoptotic proteins. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Furthermore, parthenolide reduced Akt phosphorylation and activated mitochondrial signalling, suggesting that the antitumour function of parthenolide may be mediated not only by the inhibition of NF-kappaB but also by the inhibition of Akt signalling and the activation of apoptotic proteins. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |