Pub. Date : 2012 Nov
PMID : 23022044
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-angiogenic effects of thioridazine involving the FAK-mTOR pathway. | Thioridazine | protein tyrosine kinase 2 | Homo sapiens |
| 2 | Thioridazine suppressed phosphorylation of the signaling regulators downstream of the focal adhesion kinase (FAK) through alphavbeta3 integrin, which also include Akt, phosphoinositide-dependent protein kinase 1 (PDK-1), mammalian target of rapamycin (mTOR), ribosomal protein S6 kinase (p70S6K), but had no effect on VEGF-stimulated extracellular signal-regulated kinase (ERK) phosphorylation. | Thioridazine | protein tyrosine kinase 2 | Homo sapiens |
| 3 | Thioridazine suppressed phosphorylation of the signaling regulators downstream of the focal adhesion kinase (FAK) through alphavbeta3 integrin, which also include Akt, phosphoinositide-dependent protein kinase 1 (PDK-1), mammalian target of rapamycin (mTOR), ribosomal protein S6 kinase (p70S6K), but had no effect on VEGF-stimulated extracellular signal-regulated kinase (ERK) phosphorylation. | Thioridazine | protein tyrosine kinase 2 | Homo sapiens |