Title : CD4+ CD25+ Foxp3+ IFNγ+ CD178+ human induced Treg (iTreg) contribute to suppression of alloresponses by apoptosis of responder cells.

Pub. Date : 2013 Feb

PMID : 23017670






6 Functional Relationships(s)
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1 Early apoptosis and necrosis rates as well as co-expression of immunostimulatory and immunosuppressive proteins in/on CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) PBL were analyzed using cells from healthy controls and four-color flow cytometry, PMA/Ionomycin-stimulated PBL, and MLC. Ionomycin CD4 molecule Homo sapiens
2 Sixteen hours PMA/Ionomycin stimulation induced iTreg subsets with the phenotype CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) co-expressing CD95, CD152, CD178, CD279, Granzyme A, Granzyme B, Perforin, IL-10, and TGFbeta(1). Ionomycin CD4 molecule Homo sapiens
3 Sixteen hours PMA/Ionomycin stimulation induced iTreg subsets with the phenotype CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) co-expressing CD95, CD152, CD178, CD279, Granzyme A, Granzyme B, Perforin, IL-10, and TGFbeta(1). Ionomycin CD4 molecule Homo sapiens
4 Sixteen hours PMA/Ionomycin stimulation induced iTreg subsets with the phenotype CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) co-expressing CD95, CD152, CD178, CD279, Granzyme A, Granzyme B, Perforin, IL-10, and TGFbeta(1). Ionomycin CD4 molecule Homo sapiens
5 CD4(+)CD25(+)IFNgamma(+) and CD4(+)CD25(+)CD178(+) PBL separated from primary cell cultures and added to autologous PMA/Ionomycin stimulated secondary cell cultures induced apoptosis immediately. Ionomycin CD4 molecule Homo sapiens
6 CD4(+)CD25(+)IFNgamma(+) and CD4(+)CD25(+)CD178(+) PBL separated from primary cell cultures and added to autologous PMA/Ionomycin stimulated secondary cell cultures induced apoptosis immediately. Ionomycin CD4 molecule Homo sapiens