Pub. Date : 2012 Nov 9
PMID : 23012366
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both the lipid-lowering drug lovastatin and the Rac1-specific inhibitor NSC23766 attenuated doxorubicin- and etoposide-stimulated H2AX phosphorylation, induction of DNA strand breaks, and topo II-DNA complex formation. | Doxorubicin | Rac family small GTPase 1 | Rattus norvegicus |
| 2 | Pharmacological inhibition of Rac1 signaling counteracts doxorubicin- and etoposide-stimulated DDR by disabling the formation of the topo II-DNA cleavable complex. | Doxorubicin | Rac family small GTPase 1 | Rattus norvegicus |