Title : Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression.

Pub. Date : 2013 Feb

PMID : 23011268






1 Functional Relationships(s)
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1 Bupropion induced the greatest effect on CREB in DISC1-Q31L mutants, whereas all studied ADs corrected the reduced levels of beta-arrestin-1,2 and modestly ameliorated deficient spine density in this brain region. Bupropion cAMP responsive element binding protein 1 Mus musculus