Pub. Date : 2012
PMID : 23008696
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PPARalpha agonists GW7647, WY14643, and gemfibrozil acutely relaxed aortas held under isometric tension and dilated pressurized MCAs with the following order of potency: GW7647>>WY14643>gemfibrozil. | pirinixic acid | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | The PPARalpha agonists GW7647, WY14643, and gemfibrozil acutely relaxed aortas held under isometric tension and dilated pressurized MCAs with the following order of potency: GW7647>>WY14643>gemfibrozil. | pirinixic acid | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | In aortas, GW7647 and WY14643 elevated cGMP levels by stimulating soluble guanylyl cyclase (sGC), and inhibition of sGC with ODQ blunted relaxations to PPARalpha agonists. | pirinixic acid | peroxisome proliferator activated receptor alpha | Mus musculus |