Title : Lack of enantioselectivity in the SULT1A3-catalyzed sulfoconjugation of normetanephrine enantiomers: an in vitro and computational study.

Pub. Date : 2013 Jan

PMID : 23008099






1 Functional Relationships(s)
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1 We confronted the kinetic parameters of the sulfoconjugation of synthetic (1R)-normetanephrine and (1S)-normetanephrine by recombinant human SULT1A3 to a docking model of each normetanephrine enantiomer with SULT1A3 and the 3"-phosphoadenosine-5"-phosphosulfate cofactor on the basis of molecular modeling and molecular dynamics simulations of the stability of the complexes. Phosphoadenosine Phosphosulfate LOC105369243 Homo sapiens