Title : ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells.

Pub. Date : 2012 Dec

PMID : 23008020






3 Functional Relationships(s)
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1 ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells. allyl isothiocyanate mitogen-activated protein kinase 1 Homo sapiens
2 Importantly, NAC (a ROS scavenger) and U0126 (an ERK inhibitor) abolished AITC-reduced viability in MDA-MB-468 cells. allyl isothiocyanate mitogen-activated protein kinase 1 Homo sapiens
3 In summary, our findings demonstrated that AITC-promoted G2/M phase and AITC-triggered apoptosis correlate with the activation of phosphorylation of ERK in MDA-MB-468 cells. allyl isothiocyanate mitogen-activated protein kinase 1 Homo sapiens