Pub. Date : 2012 Nov 16
PMID : 23007396
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes, are required for hair follicle (hf) morphogenesis. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 2 | In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes, are required for hair follicle (hf) morphogenesis. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 3 | Mice with embryonic ablation of Cyp26b1 (Cyp26b1(-/-)) have excessive endogenous RA, resulting in arrest of hf growth at the hair germ stage. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 4 | Mice with embryonic ablation of Cyp26b1 (Cyp26b1(-/-)) have excessive endogenous RA, resulting in arrest of hf growth at the hair germ stage. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 5 | Conditional deficiency of Cyp26b1 in the dermis (En1Cre;Cyp26b1f/-) results in decreased hair follicle density and specific effect on hair type, indicating that RA levels also influence regulators of hair bending. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 6 | To elucidate target gene pathways of RA, we performed microarray and RNA-Seq profiling of genes differentially expressed in Cyp26b1(-/-) skin and En1Cre;Cyp26b1f/- tissues. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 7 | To elucidate target gene pathways of RA, we performed microarray and RNA-Seq profiling of genes differentially expressed in Cyp26b1(-/-) skin and En1Cre;Cyp26b1f/- tissues. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |