PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23007396-3 2012 In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes, are required for hair follicle (hf) morphogenesis. Tretinoin 61-63 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 78-85 23007396-3 2012 In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes, are required for hair follicle (hf) morphogenesis. Tretinoin 98-100 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 78-85 23007396-4 2012 Mice with embryonic ablation of Cyp26b1 (Cyp26b1(-/-)) have excessive endogenous RA, resulting in arrest of hf growth at the hair germ stage. Tretinoin 81-83 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 32-39 23007396-4 2012 Mice with embryonic ablation of Cyp26b1 (Cyp26b1(-/-)) have excessive endogenous RA, resulting in arrest of hf growth at the hair germ stage. Tretinoin 81-83 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 41-48 23007396-7 2012 Conditional deficiency of Cyp26b1 in the dermis (En1Cre;Cyp26b1f/-) results in decreased hair follicle density and specific effect on hair type, indicating that RA levels also influence regulators of hair bending. Tretinoin 161-163 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 26-33 23007396-9 2012 To elucidate target gene pathways of RA, we performed microarray and RNA-Seq profiling of genes differentially expressed in Cyp26b1(-/-) skin and En1Cre;Cyp26b1f/- tissues. Tretinoin 37-39 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 124-131 23007396-9 2012 To elucidate target gene pathways of RA, we performed microarray and RNA-Seq profiling of genes differentially expressed in Cyp26b1(-/-) skin and En1Cre;Cyp26b1f/- tissues. Tretinoin 37-39 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 153-160