Title :  Dehydroepiandrosterone sulfate, osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia nervosa.

Pub. Date : 2012 Sep 12

PMID : 23001207






4 Functional Relationships(s)
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1 A significant positive correlation was also observed between DHEAS and the OPG/sRANKL ratio, OC and the OPG/sRANKL ratio, and CTx and sRANKL. Dehydroepiandrosterone TNF receptor superfamily member 11b Homo sapiens
2 DISCUSSION/CONCLUSIONS: DHEAS suppression in girls with anorexia nervosa was associated with a decrease in the levels of bone markers, an increase in OPG and sRANKL concentrations and a significant decrease in the OPG/sRANKL ratio. Dehydroepiandrosterone TNF receptor superfamily member 11b Homo sapiens
3 DISCUSSION/CONCLUSIONS: DHEAS suppression in girls with anorexia nervosa was associated with a decrease in the levels of bone markers, an increase in OPG and sRANKL concentrations and a significant decrease in the OPG/sRANKL ratio. Dehydroepiandrosterone TNF receptor superfamily member 11b Homo sapiens
4 DHEAS suppression in girls with anorexia nervosa might have a harmful effect on their bone tissue, probably via a shift in the OPG/RANKL ratio toward a functional excess of sRANKL. Dehydroepiandrosterone TNF receptor superfamily member 11b Homo sapiens