Protein Name TNF receptor superfamily member 11b
Organism Homo sapiens
Gene ID 4982
Gene Symbol

TNFRSF11B

UniProt O00300 (TR11B_HUMAN)
Relationships Total Number of functionally related compound(s) : 502
Total Number of Articles : 736
Description

TNF receptor superfamily member 11b

Gene Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

synonyms
  • tumor necrosis factor receptor superfamily member 11B
  • osteoclastogenesis inhibitory factor
  • osteoprotegerin
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Properties