Pub. Date : 2012 Dec
PMID : 22992944
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitro. | Platinum | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | AKT overexpression (confirmed by western blotting) converted platinum-sensitive A2780 into platinum-resistant cells as shown by MTT assay. | Platinum | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | AKT overexpression (confirmed by western blotting) converted platinum-sensitive A2780 into platinum-resistant cells as shown by MTT assay. | Platinum | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Importantly, platinum resistance of A2780cis cells could be reversed by downregulation of AKT, as demonstrated by MTT and clonogenicity assays and FACS analysis. | Platinum | AKT serine/threonine kinase 1 | Homo sapiens |