PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22992944-0 2012 Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitro. Platinum 31-39 AKT serine/threonine kinase 1 Homo sapiens 18-21 22992944-7 2012 AKT overexpression (confirmed by western blotting) converted platinum-sensitive A2780 into platinum-resistant cells as shown by MTT assay. Platinum 73-81 AKT serine/threonine kinase 1 Homo sapiens 0-3 22992944-7 2012 AKT overexpression (confirmed by western blotting) converted platinum-sensitive A2780 into platinum-resistant cells as shown by MTT assay. Platinum 103-111 AKT serine/threonine kinase 1 Homo sapiens 0-3 22992944-8 2012 Importantly, platinum resistance of A2780cis cells could be reversed by downregulation of AKT, as demonstrated by MTT and clonogenicity assays and FACS analysis. Platinum 13-21 AKT serine/threonine kinase 1 Homo sapiens 102-105