Pub. Date : 2012 Nov
PMID : 22990467
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway. | Fatty Acids | NPC intracellular cholesterol transporter 1 | Mus musculus |
| 2 | The key results showed that the Npc1 gene was downregulated by dietary fatty acids (54%, P = 0.022), but not by dietary cholesterol, through feedback inhibition of the sterol regulatory element-binding protein (SREBP) pathway. | Fatty Acids | NPC intracellular cholesterol transporter 1 | Mus musculus |
| 3 | These results are important because they suggest a novel mechanism for the interaction of fatty acids with the Npc1 gene to influence energy balance and to promote weight gain. | Fatty Acids | NPC intracellular cholesterol transporter 1 | Mus musculus |
| 4 | Moreover, the responsiveness of the Npc1 gene to fatty acids is consistent with studies that suggest that the encoded NPC1 protein has a physiologic role in regulating both cholesterol and fatty acid metabolism. | Fatty Acids | NPC intracellular cholesterol transporter 1 | Mus musculus |
| 5 | Moreover, the responsiveness of the Npc1 gene to fatty acids is consistent with studies that suggest that the encoded NPC1 protein has a physiologic role in regulating both cholesterol and fatty acid metabolism. | Fatty Acids | NPC intracellular cholesterol transporter 1 | Mus musculus |
| 6 | Moreover, the responsiveness of the Npc1 gene to fatty acids is consistent with studies that suggest that the encoded NPC1 protein has a physiologic role in regulating both cholesterol and fatty acid metabolism. | Fatty Acids | NPC intracellular cholesterol transporter 1 | Mus musculus |
| 7 | Moreover, the responsiveness of the Npc1 gene to fatty acids is consistent with studies that suggest that the encoded NPC1 protein has a physiologic role in regulating both cholesterol and fatty acid metabolism. | Fatty Acids | NPC intracellular cholesterol transporter 1 | Mus musculus |