Pub. Date : 2012 Dec
PMID : 22985884
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our study provides evidence that the seesaw effect applies to other beta-lactams and carbapenems of clinical use, including nafcillin (NAF), cefotaxime (CTX), amoxicillin-clavulanic (AMC), and imipenem (IMP), in heterogeneous DAP(r) MRSA strains but not in MRSA strains expressing homogeneous beta-lactam resistance. | beta-Lactams | death associated protein | Homo sapiens |
| 2 | Our study provides evidence that the seesaw effect applies to other beta-lactams and carbapenems of clinical use, including nafcillin (NAF), cefotaxime (CTX), amoxicillin-clavulanic (AMC), and imipenem (IMP), in heterogeneous DAP(r) MRSA strains but not in MRSA strains expressing homogeneous beta-lactam resistance. | beta-Lactams | death associated protein | Homo sapiens |
| 3 | In these models, DAP and a beta-lactam proved to be highly synergistic against both heterogeneous and homogeneous clinical DAP(r) MRSA strains. | beta-Lactams | death associated protein | Homo sapiens |
| 4 | Mechanistically, beta-lactams induced a reduction in the cell net positive surface charge, reverting the increased repulsion provoked by DAP alone, an effect that may favor the binding of DAP to the cell surface. | beta-Lactams | death associated protein | Homo sapiens |
| 5 | Mechanistically, beta-lactams induced a reduction in the cell net positive surface charge, reverting the increased repulsion provoked by DAP alone, an effect that may favor the binding of DAP to the cell surface. | beta-Lactams | death associated protein | Homo sapiens |
| 6 | Importantly, the combination of DAP and a beta-lactam prevented the selection of DAP(r) variants. | beta-Lactams | death associated protein | Homo sapiens |