Pub. Date : 2013 Mar
PMID : 22982753
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 2 | PGE2 has been shown to elevate the IL-23 production by dendritic cells (DC). | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 3 | Monocytes are also producers of IL-23 but the effect of PGE2 on IL-23 production by human monocytes has hardly been investigated. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 4 | We show here that PGE2 blocks the production of IL-23 by LPS-stimulated monocytes in an IL-10 and IL-1beta independent manner. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 5 | These effects of PGE2 were cAMP-dependent since the cAMP enhancer forskolin strongly reduced IL-23 and IL-12 production by monocytes. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 6 | Taken together, PGE2 acts in an anti-inflammatory manner by lowering IL-23 production by monocytes while it has the opposite effect in DC. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |