Pub. Date : 2012 Oct 30
PMID : 22982730
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alpha-lipoic acid pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling. | Thioctic Acid | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell (CEC) injury by activating the Akt/mTOR pathway. | Thioctic Acid | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Western blotting showed that the ALA pre- and post-treatments up-regulated the phosphorylation of Akt, mTOR, S6K and 4E-BP1 in both bEnd.3 cells and primary cultures. | Thioctic Acid | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | However, after pre-treatment with rapamycin, the level of Akt phosphorylation was decreased in primary cultures of CECs but could still be restored by ALA, whereas the levels of mTOR, S6K and 4E-BP1 phosphorylation were significantly decreased and could not be restored. | Thioctic Acid | thymoma viral proto-oncogene 1 | Mus musculus |
| 5 | These results suggest that ALA pre- and post-treatments provide protective effects against simulated ischemia and reperfusion-induced CEC injury by promoting the Akt/mTOR pathway and that mTOR is required for ALA protection. | Thioctic Acid | thymoma viral proto-oncogene 1 | Mus musculus |