Title : Mevalonate-suppressive dietary isoprenoids for bone health.

Pub. Date : 2012 Dec

PMID : 22981371






1 Functional Relationships(s)
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1 The tocotrienols, vitamin E molecules with HMG CoA reductase-suppressive activity, induce mevalonate deprivation and concomitantly suppress the expression of RANKL and cyclooxygenase-2, the production of prostaglandin E2 and the activation of NFkappaB. Tocotrienols prostaglandin-endoperoxide synthase 2 Homo sapiens