Title : Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis.

Pub. Date : 2012 Sep 14

PMID : 22974127






1 Functional Relationships(s)
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1 RESULTS: Data indicated that simvastatin inhibited intrinsic cell survival pathway in PC3 cells by enhancing phosphorylation of Bad, reducing the protein expression of Bcl-2, Bcl-xL and cleaved caspases 9/3. Simvastatin caspase 9 Homo sapiens