Pub. Date : 2012 Sep 15
PMID : 22960764
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: After whole-blood activation with the gamma(c) cytokines IL-2, IL-7, and IL-15, STAT5 phosphorylation was determined in T cells of de novo kidney transplantation patients treated with tofacitinib/basiliximab (n=5), calcineurin inhibitor (CNI) (cyclosporine A)/basiliximab (n=4) or CNI (tacrolimus)-based immunosuppression (n=6). | tofacitinib | signal transducer and activator of transcription 5A | Homo sapiens |
| 2 | In kidney transplantation patients, 7 days after starting tofacitinib/basiliximab treatment, cytokine-induced P-STAT5 was inhibited in CD4(+) T cells (92% for IL-2 activation, 60% for IL-7, and 75% for IL-15), which persisted for the 2-month study period. | tofacitinib | signal transducer and activator of transcription 5A | Homo sapiens |
| 3 | CONCLUSIONS: Tofacitinib therapy strongly inhibits gamma(c) cytokine-induced JAK/STAT5 activation, whereas basiliximab suppresses IL-2-stimulated activation only. | tofacitinib | signal transducer and activator of transcription 5A | Homo sapiens |