Pub. Date : 2012
PMID : 22952803
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating alpha7AChR, ERK, HIF-1alpha and VEGF/PEDF signaling. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The mechanism studies showed that the observed stimulation of proliferation was accompanied by the nicotine-mediated simultaneous modulation of alpha7AChR, HIF-1alpha, ERK and VEGF/PEDF signaling. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Nicotine also promoted the phosphorylation of ERK1/2 but not JNK and p38 proteins, thereby induced the activation of ERK/MAPK signaling pathway. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Pretreatment with an ERK-selective inhibitor effectively reduced the nicotine-induced proliferation of NPC cells. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Pretreatment with a alpha7AChR or ERK-selective inhibitor or transfection with a HIF-1alpha-specific siRNA in NPC cells significantly inhibited the nicotine-induced HIF-1alpha expression and VEGF/PEDF ratio. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | These results therefore indicate that nicotine promotes proliferation of human NPC cells in vitro through simultaneous modulation of alpha7AChR, HIF-1alpha, ERK and VEGF/PEDF signaling and suggest that the related molecules such as HIF-1alpha might be the potential therapeutic targets for tobacco-associated diseases such as nasopharyngeal carcinomas. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |