Title : Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways.

Pub. Date : 2012 Oct

PMID : 22943182






3 Functional Relationships(s)
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1 In this study, we examined the effects and possible underlying mechanisms of berberine in Abeta-induced neuroinflammation using murine primary microglia cells and cultured BV2 microglia cells. Berberine amyloid beta (A4) precursor protein Mus musculus
2 METHODS: The effects of berberine on Abeta-stimulated inflammatory factor expression and secretion were examined using RT-PCR and ELISA analysis. Berberine amyloid beta (A4) precursor protein Mus musculus
3 RESULTS: In primary microglial and BV2 cells, berberine treatment significantly inhibited Abeta-stimulated production of interleukin-6 and monocyte chemotactic protein-1. Berberine amyloid beta (A4) precursor protein Mus musculus