Title : Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

Pub. Date : 2012 Oct 11

PMID : 22934537






1 Functional Relationships(s)
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1 Biochemical characterization of a library of 13 oxygenated polyketides isolated from the marine sponge Plakinastrella mamillaris allowed the discovery of gracilioether B and plakilactone C as selective PPARgamma ligands in transactivation assays. Polyketides peroxisome proliferator activated receptor gamma Homo sapiens