Pub. Date : 2013 Jan
PMID : 22933114
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic beta-cells. | Glucose | BCL2-like 1 | Mus musculus |
| 2 | In this study, we demonstrate that chemical and genetic loss-of-function of antiapoptotic Bcl-2 and Bcl-x(L) significantly augments glucose-dependent metabolic and Ca(2+) signals in primary pancreatic beta-cells. | Glucose | BCL2-like 1 | Mus musculus |
| 3 | Antagonism of Bcl-2/Bcl-x(L) by two distinct small-molecule compounds rapidly hyperpolarized beta-cell mitochondria, increased cytosolic Ca(2+), and stimulated insulin release via the ATP-dependent pathway in beta-cell under substimulatory glucose conditions. | Glucose | BCL2-like 1 | Mus musculus |
| 4 | Inducible deletion of Bcl-x(L) in adult mouse beta-cells also increased glucose-stimulated NAD(P)H and Ca(2+) responses and resulted in an improvement of in vivo glucose tolerance in the conditional Bcl-x(L) knockout animals. | Glucose | BCL2-like 1 | Mus musculus |
| 5 | Inducible deletion of Bcl-x(L) in adult mouse beta-cells also increased glucose-stimulated NAD(P)H and Ca(2+) responses and resulted in an improvement of in vivo glucose tolerance in the conditional Bcl-x(L) knockout animals. | Glucose | BCL2-like 1 | Mus musculus |
| 6 | Inducible deletion of Bcl-x(L) in adult mouse beta-cells also increased glucose-stimulated NAD(P)H and Ca(2+) responses and resulted in an improvement of in vivo glucose tolerance in the conditional Bcl-x(L) knockout animals. | Glucose | BCL2-like 1 | Mus musculus |
| 7 | Inducible deletion of Bcl-x(L) in adult mouse beta-cells also increased glucose-stimulated NAD(P)H and Ca(2+) responses and resulted in an improvement of in vivo glucose tolerance in the conditional Bcl-x(L) knockout animals. | Glucose | BCL2-like 1 | Mus musculus |