Title : Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells.

Pub. Date : 2012 Nov 30

PMID : 22932446






2 Functional Relationships(s)
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1 On the other hand, kurarinone significantly inhibited TRAIL-induced IKK activation, IkappaB degradation and nuclear translocation of NF-kappaB, as well as effectively suppressed cellular FLICE-inhibitory protein long form (cFLIPL) expression. kurarinone CASP8 and FADD like apoptosis regulator Homo sapiens
2 The synergistic effects of kurarinone on TRAIL-induced apoptosis were mimicked when kurarinone was replaced by the NF-kappaB inhibitor withaferin A or following siRNA-mediated knockdown of cFLIPL. kurarinone CASP8 and FADD like apoptosis regulator Homo sapiens