Title : Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.

Pub. Date : 2012 Sep 27

PMID : 22928944






1 Functional Relationships(s)
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1 In this study, a cocrystal structure of the acetylcholine binding protein (AChBP) from Capitella teleta (Ct) in complex with a cyclopropane-containing selective alpha4beta2-nicotinic acetylcholine receptor (nAChR) partial agonist (compound 5) was acquired. cyclopropane cholinergic receptor nicotinic alpha 4 subunit Homo sapiens