Title : Reversine induces cell cycle arrest, polyploidy, and apoptosis in human breast cancer cells.

Pub. Date : 2014 May

PMID : 22926505






1 Functional Relationships(s)
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1 Apoptosis in reversine-treated cells was exhibited with PARP cleavage and caspase-3 and caspase-8 activation, but not caspase-9 activation, indicating that caspase-dependent apoptosis mediated by an extrinsic pathway took place in reversine-treated cells. 2-(4-morpholinoanilino)-6-cyclohexylaminopurine caspase 8 Homo sapiens