Pub. Date : 2012 Oct 15
PMID : 22923641
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of primary cultures of BEC with nicotine increased levels of nAChR subunits and that increase was potentiated by lynx1 knockdown. | Nicotine | Ly6/neurotoxin 1 | Homo sapiens |
| 2 | Lynx1 knockdown also potentiated the nicotine-induced increase in GABA(A) receptors (GABA(A)R) and MUC5AC mRNA expression, and that effect was blocked by alpha7 antagonists and alpha7 knockdown. | Nicotine | Ly6/neurotoxin 1 | Homo sapiens |
| 3 | Consistent with this, inhibition of Src signaling blocked the ability of the lynx1 knockdown to increase basal and nicotine-stimulated GABA(A)R and mucin mRNA expression. | Nicotine | Ly6/neurotoxin 1 | Homo sapiens |