Title : Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2.

Pub. Date : 2012 Nov

PMID : 22923287






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
2 Furthermore, individual or combined treatment with EGCG and gefitinib suppressed the protein expression of p-EGFR and the phosphorylated protein levels of ERK, JNK, p38 and AKT and displayed inhibitory effects on metastatic ability of CAL-27 cells. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
3 Importantly, EGCG sensitizes CAL-27 cells to gefitinib-suppressed phosphorylation of epidermal growth factor receptor (EGFR in vitro. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
4 Importantly, EGCG sensitizes CAL-27 cells to gefitinib-suppressed phosphorylation of epidermal growth factor receptor (EGFR in vitro. epigallocatechin gallate epidermal growth factor receptor Homo sapiens