Title : Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes.

Pub. Date : 2012

PMID : 22912718






3 Functional Relationships(s)
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1 Here, we demonstrate that in cardiomyocytes, palmitoylation of beta(2)AR, the covalent acylation of cysteine residue 341, plays a critical role in shaping subcellular cAMP-PKA activities in cardiomyocytes via regulating beta(2)AR association with arrestin/PDE4D. Cysteine adrenoceptor beta 2 Homo sapiens
2 Here, we demonstrate that in cardiomyocytes, palmitoylation of beta(2)AR, the covalent acylation of cysteine residue 341, plays a critical role in shaping subcellular cAMP-PKA activities in cardiomyocytes via regulating beta(2)AR association with arrestin/PDE4D. Cysteine adrenoceptor beta 2 Homo sapiens
3 Replacing cysteine 341 on beta(2)AR with alanine (C341A) leads to an impaired binding to beta arrestin 2. Cysteine adrenoceptor beta 2 Homo sapiens