Pub. Date : 2012 Sep 24
PMID : 22893598
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The assay is based on the specific interaction of CDK2 with the extrinsic fluorophore 8-anilino-1-naphthalene sulfonate (ANS), which binds to a large allosteric pocket adjacent to the ATP site. | 8-anilino-1-naphthalenesulfonic acid | cyclin dependent kinase 2 | Homo sapiens |
| 2 | The assay is based on the specific interaction of CDK2 with the extrinsic fluorophore 8-anilino-1-naphthalene sulfonate (ANS), which binds to a large allosteric pocket adjacent to the ATP site. | 8-anilino-1-naphthalenesulfonic acid | cyclin dependent kinase 2 | Homo sapiens |
| 3 | Hit compounds that displace ANS directly or indirectly from CDK2 are readily classified as ATP site binders or allosteric ligands through the use of staurosporine, which blocks the ATP site without displacing ANS. | 8-anilino-1-naphthalenesulfonic acid | cyclin dependent kinase 2 | Homo sapiens |
| 4 | Hit compounds that displace ANS directly or indirectly from CDK2 are readily classified as ATP site binders or allosteric ligands through the use of staurosporine, which blocks the ATP site without displacing ANS. | 8-anilino-1-naphthalenesulfonic acid | cyclin dependent kinase 2 | Homo sapiens |