Pub. Date : 2012 Sep
PMID : 22886304
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that PML acted as both a negative regulator of PPARgamma coactivator 1A (PGC1A) acetylation and a potent activator of PPAR signaling and fatty acid oxidation. | Fatty Acids | PML nuclear body scaffold | Homo sapiens |
| 2 | Importantly, PML expression allowed luminal filling in 3D basement membrane breast culture models, an effect that was reverted by the pharmacological inhibition of fatty acid oxidation. | Fatty Acids | PML nuclear body scaffold | Homo sapiens |
| 3 | These findings have important therapeutic implications, as PML and its key role in fatty acid oxidation metabolism are amenable to pharmacological suppression, a potential future mode of cancer prevention and treatment. | Fatty Acids | PML nuclear body scaffold | Homo sapiens |