Pub. Date : 2013 Jul 11
PMID : 22869149
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A whole genome microarray analysis, using a BT474 cell line, reveals genes significantly modulated (positively or negatively) after LMTK3 silencing, including some that are known to be implicated in Tam resistance, notably c-MYC, HSPB8 and SIAH2. | Tamoxifen | heat shock protein family B (small) member 8 | Homo sapiens |
| 2 | We show that LMTK3 is able to increase the levels of HSPB8 at a transcriptional and translational level thereby protecting MCF7 cells from Tam-induced cell death, by reducing autophagy. | Tamoxifen | heat shock protein family B (small) member 8 | Homo sapiens |