Title : Progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux: design, synthesis, characterization and biological evaluation.

Pub. Date : 2012 Oct

PMID : 22868178






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Bivalent ligands were designed on the basis of the described close proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). Steroids ATP binding cassette subfamily B member 1 Homo sapiens
2 Bivalent ligands were designed on the basis of the described close proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). Steroids ATP binding cassette subfamily B member 1 Homo sapiens