Title : Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes.

Pub. Date : 2013 Jan

PMID : 22864849






1 Functional Relationships(s)
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1 Taken together, these results suggest that chrysin, apigenin, and luteolin inhibit tBHP-induced oxidative stress by up-regulating HO-1, GCLC, and GCLM gene transcription via the ERK2/Nrf2/ARE signaling pathways in rat primary hepatocytes. tert-Butylhydroperoxide glutamate-cysteine ligase, catalytic subunit Rattus norvegicus