Protein Name glutamate-cysteine ligase, catalytic subunit
Organism Rattus norvegicus
Gene ID 25283
Gene Symbol

Gclc

UniProt P19468 (GSH1_RAT)
Relationships Total Number of functionally related compound(s) : 217
Total Number of Articles : 293
Description

glutamate-cysteine ligase, catalytic subunit

Gene Summary

Enables glutamate-cysteine ligase activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to hepatocyte growth factor stimulus; and cellular response to mechanical stimulus. Part of glutamate-cysteine ligase complex. Used to study liver cirrhosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • glutamate--cysteine ligase catalytic subunit
  • GCS heavy chain
  • Glutamylcysteine gamma synthetase light chain
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Properties