Title : "Clicked" sugar-curcumin conjugate: modulator of amyloid-β and tau peptide aggregation at ultralow concentrations.

Pub. Date : 2011 Dec 21

PMID : 22860163






4 Functional Relationships(s)
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1 "Clicked" sugar-curcumin conjugate: modulator of amyloid-beta and tau peptide aggregation at ultralow concentrations. Curcumin microtubule associated protein tau Homo sapiens
2 The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-beta and tau peptide aggregation is presented. Curcumin microtubule associated protein tau Homo sapiens
3 Curcumin inhibits amyloid-beta and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Abeta and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. Curcumin microtubule associated protein tau Homo sapiens
4 Curcumin inhibits amyloid-beta and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Abeta and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. Curcumin microtubule associated protein tau Homo sapiens