Pub. Date : 2012 Nov
PMID : 22859313
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2. | Bilirubin | heme oxygenase 1 | Mus musculus |
2 | Similar subcellular targeting and coordination of CYP2A5 and HMOX1 responses suggest favorable conditions for enhanced CYP2A5-mediated bilirubin maintenance in altered heme homeostasis that predisposes to oxidative stress. | Bilirubin | heme oxygenase 1 | Mus musculus |