Pub. Date : 2012
PMID : 22844454
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyproheptadine enhances the I(K) of mouse cortical neurons through sigma-1 receptor-mediated intracellular signal pathway. | Cyproheptadine | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 2 | Antagonists of the sigma-1 receptor, however, blocked the effect of CPH. | Cyproheptadine | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 3 | On the contrary, sigma-1 receptor agonist mimicked the effects of CPH on the induction of I(K). | Cyproheptadine | sigma non-opioid intracellular receptor 1 | Mus musculus |
| 4 | In overall, we reveal for the first time that CPH enhances the I(K) by modulating activity of PKA, and that the associated activation of the sigma-1 receptor/G(i)-protein pathway might be involved. | Cyproheptadine | sigma non-opioid intracellular receptor 1 | Mus musculus |