Pub. Date : 2013 Jan
PMID : 22841916
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. | Caffeine | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | Because brain-derived neurotrophic factor (BDNF) is associated with memory formation and BDNF"s actions are modulated by adenosine receptors, the molecular targets for the psychostimulant actions of caffeine, we here compare the effects of chronic caffeine (1 mg/mL drinking solution for 30 days) on short- and long term memory and on levels of hippocampal proBDNF, mature BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats. | Caffeine | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | Because brain-derived neurotrophic factor (BDNF) is associated with memory formation and BDNF"s actions are modulated by adenosine receptors, the molecular targets for the psychostimulant actions of caffeine, we here compare the effects of chronic caffeine (1 mg/mL drinking solution for 30 days) on short- and long term memory and on levels of hippocampal proBDNF, mature BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats. | Caffeine | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | Because brain-derived neurotrophic factor (BDNF) is associated with memory formation and BDNF"s actions are modulated by adenosine receptors, the molecular targets for the psychostimulant actions of caffeine, we here compare the effects of chronic caffeine (1 mg/mL drinking solution for 30 days) on short- and long term memory and on levels of hippocampal proBDNF, mature BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats. | Caffeine | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | Caffeine treatment substantially reduced i) age-related impairments in the two types of memory in an inhibitory avoidance paradigm, and ii) parallel increases in hippocampal BDNF levels. | Caffeine | brain-derived neurotrophic factor | Rattus norvegicus |
| 6 | These data provide new evidence in favor of the hypothesis that modifications in BDNF and related proteins in the hippocampus contribute to the pro-cognitive effects of caffeine on age-associated losses in memory encoding. | Caffeine | brain-derived neurotrophic factor | Rattus norvegicus |