Title : Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies.

Pub. Date : 2012 Mar

PMID : 22829255






1 Functional Relationships(s)
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1 Heterologously expressed MCL-1 substituted for FLT3 signaling by conferring resistance of hematopoietic cells to antileukemia drugs such as cytarabine and daunorubicin, and to the proapoptotic BH3 mimetic ABT-737. Daunorubicin MCL1 apoptosis regulator, BCL2 family member Homo sapiens