Pub. Date : 2011 Dec
PMID : 22829094
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AZD1480 at low doses (0.1-1 mu) potently inhibited STATs phosphorylation, but did not predictably result in antiproliferative effects, as it activated a negative-feedback loop causing phosphorylation of JAK2 and extracellular signal-regulated kinases 1 and 2 (ERK1/2), and increased IP-10, RANTES and interleukin (IL)-8 concentrations in the supernatants. | AZD 1480 | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Inhibition of the ERK activity by mitogen-activated extracellular signal regulated kinase (MEK) inhibitors (UO126 and PD98059) enhanced the cytotoxic activity of AZD1480. | AZD 1480 | mitogen-activated protein kinase 3 | Homo sapiens |