Title : Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: a role for STAT1 and MAPK pathways.

Pub. Date : 2012 Oct

PMID : 22823229






3 Functional Relationships(s)
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1 We have previously reported that transforming growth factor beta1 (TGFbeta1) released by hippocampal cells modulates interferon-gamma (IFNgamma)-induced production of O(2) (-) and NO by glial cells. Superoxides interferon gamma Homo sapiens
2 We have previously reported that transforming growth factor beta1 (TGFbeta1) released by hippocampal cells modulates interferon-gamma (IFNgamma)-induced production of O(2) (-) and NO by glial cells. Superoxides interferon gamma Homo sapiens
3 We found that costimulation with TGFbeta1 decreased IFNgamma-induced phosphorylation of signal transducer and activator of transcription-type-1 (STAT1) and extracellular signal-regulated kinase (ERK), which correlated with a reduced O(2) (-) and NO production in mixed and purified glial cultures. Superoxides interferon gamma Homo sapiens