Pub. Date : 2012 Nov 1
PMID : 22820234
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |
| 2 | Chronic administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein levels in the amygdala and this enhancement was suppressed by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor SL327. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |
| 3 | Chronic administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein levels in the amygdala and this enhancement was suppressed by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor SL327. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |
| 4 | Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |
| 5 | Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |
| 6 | Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |
| 7 | Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |
| 8 | These results suggest that the antidepressant-like effects of curcumin in the forced swim test are mediated, at least in part, by an ERK-regulated increase of BDNF expression in the amygdala of mice. | Curcumin | mitogen-activated protein kinase 1 | Mus musculus |