PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22820234-0	2012	Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice.	Curcumin	0-8	mitogen-activated protein kinase 1	Mus musculus	61-64	
22820234-5	2012	Chronic administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein levels in the amygdala and this enhancement was suppressed by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor SL327.	Curcumin	26-34	mitogen-activated protein kinase 1	Mus musculus	168-205	
22820234-5	2012	Chronic administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein levels in the amygdala and this enhancement was suppressed by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor SL327.	Curcumin	26-34	mitogen-activated protein kinase 1	Mus musculus	207-210	
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	76-84	mitogen-activated protein kinase 1	Mus musculus	38-41	
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	76-84	mitogen-activated protein kinase 1	Mus musculus	105-108	
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	190-198	mitogen-activated protein kinase 1	Mus musculus	38-41	
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	190-198	mitogen-activated protein kinase 1	Mus musculus	105-108	
22820234-8	2012	These results suggest that the antidepressant-like effects of curcumin in the forced swim test are mediated, at least in part, by an ERK-regulated increase of BDNF expression in the amygdala of mice.	Curcumin	62-70	mitogen-activated protein kinase 1	Mus musculus	133-136