Pub. Date : 2012 Dec
PMID : 22814742
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate. | epigallocatechin gallate | cyclin D1 | Homo sapiens |
| 2 | RESULTS: We identified cyclin D1 and p21 as molecular targets of EGCG in human colorectal cancer cells. | epigallocatechin gallate | cyclin D1 | Homo sapiens |
| 3 | Furthermore, we found EGCG decreased cyclin D1 protein stability, therefore triggering ubiquitin-dependent proteasomal degradation. | epigallocatechin gallate | cyclin D1 | Homo sapiens |
| 4 | Namely, EGCG-induced cyclin D1 degradation and p21 transcriptional activation partially contribute to growth suppression in these cells. | epigallocatechin gallate | cyclin D1 | Homo sapiens |