Title : [Role of ABCB1 and ABCG2 in the multidrug resistance of hypopharyngeal carcinoma FaDu cell line].

Pub. Date : 2012 Apr

PMID : 22800348






3 Functional Relationships(s)
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Protein Name
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1 JNK signal was inhibited in FaDu or FaDu/T cells and the inhibited JNK was reactivated by taxol or anisomycin (an activator for MAPK signal transduction pathways). Anisomycin mitogen-activated protein kinase 8 Homo sapiens
2 JNK signal was inhibited in FaDu or FaDu/T cells and the inhibited JNK was reactivated by taxol or anisomycin (an activator for MAPK signal transduction pathways). Anisomycin mitogen-activated protein kinase 8 Homo sapiens
3 Anisomycin down-regulated the expression of ABCB1 (F = 33.72, P < 0.05) and up-regulated the expression of ABCG2 (F = 220.16, P < 0.05) in FaDu/T cells, but not in FaDu/T cells pretreated by JNK inhibitor SP600125 (P > 0.05). Anisomycin mitogen-activated protein kinase 8 Homo sapiens